CLinicopathological characteristics of extranodal marginal zone B‐cell lymphoma of the intestine: a single center analysis

Extranodal marginal zone B-cell lymphoma of the mucosa associated lymphoid tissue (MALT-lymphoma) is mot commonly diagnosed in stomach (30%–35%), but exceedingly rare intestinal tract (2%). Consequently, data on this special subgroup are scarce. Out 484 patients with MALt-lymphoma and treated at our institution from 1999 to 2020, 42 (11%) had involvement (24 primary 18 secondary) were restrospectively analyzed. rated as secondary invlevement, 14 gastric MALT-lymphoma origin. Median age diagnosis was 67 years (interquartile range (IQR) 53–72) median follow-up time 47 months (IQR 32–102). Patients presenting lymphoma-associated symptoms significantly more common group versus MALT lymphomas (52% vs. 20%, p = .047). Nine each, i.e. 9/18 9/24 found positive for Helicobacter pylori. Intestinal organs involved included colon (n 19), duodenum 11), small intestine 8) rectum 5). MALT-IPI could be calculated 39 patients, low documented 37/39 cases. Seven translocation t(11;18)(q21;q21), 6 whom lymphoma, suggesting presence highly suggestive involvement. Treatment available 41 those patients. Eleven (27%) received local therapy (ten surgery, one radiotherapy, complete response rate 90%), 16 (38%) systemic (overall 87%) 9 (22%) only antibiotic (complete 38%). 4/41 watchfuil waiting applied. Eighteen progressed during follow-up; progression free survival following first line 50 mos (CI: 38.4–53.7 mos), anumerical trend towards longer PFS (134 mos) lmyphoma (35.5 mos). The estimated overall 301 months, having died follow up (two progression, other 4 unrelated conditions). A comparison terms Os cohort 144 MALT-lmyphoma showed no significant difference outcome. Overall, appear have a good prognosis irrespcetive or involvement, whichbappears comparable obtined MALT-lymphoma. Keyword: non-Hodgkin No conflicts interests pertinent abstract.